Which statement is not applicable to Fresh Frozen Plasma (FFP)?

• A. Contains all factors and fibrinogen at a slightly reduced level
• B. Frozen within 8 hours of collection
• C. Used to treat multiple coagulation factor deficiencies
• D. Thawed FFP can be used for warfarin reversal in emergent settings

Answer: (D)

Fresh Frozen Plasma provides a broad replenishment of coagulation factors, making it useful for correcting deficiencies when specific factor concentrates aren’t available. It is prepared by separating plasma and freezing it promptly, typically within 8 hours of collection, to preserve factor activity. FFP contains all coagulation factors and fibrinogen, though the exact levels can vary and some labile factors may not be fully preserved after storage. It is indeed used to treat deficiencies affecting multiple factors. In contrast, for emergent warfarin reversal the fastest and most reliable option is prothrombin complex concentrate, which rapidly replenishes vitamin K–dependent factors in a concentrated form and with less overall volume. Thawed FFP can be used for reversal when PCC isn’t available, but in true emergent settings it is not the preferred choice.